Showing posts with label Heart. Show all posts
Showing posts with label Heart. Show all posts
Antioxidants Can Prevent Heart Disease Caused by Alcohol
Antioxidants Can Prevent Heart Disease Caused by Alcohol
An antioxidant may prevent liver damage or liver caused by excessive alcohol consumption, according to research from the University of Alabama at Birmingham.
These findings could indicate how treatments to reverse steatosis, or fatty deposits in the liver that can lead to sirkosis and cancer. The research team led by Victor Darley-Usmar, Ph.D., professor of pathology at UAB, introduced an antioxidant called mitochondria-targeted ubiquinone, or MitoQ, to the mitochondria rats given alcohol every day for five to six weeks in an amount sufficient to Excessive alcohol consumption is equal to humans.
Chronic alcoholics, those who drink excessively every day, experiencing accumulation of fat in liver cells. When alcohol is metabolized in the liver, he creates free radicals that damage mitochondria in liver cells and prevent them to use a sufficient amount of oxygen to produce energy. Moreover, the low oxygen condition called hypoxia worsens mitochondrial damage and support the formation of fatty deposits that can lead to sirkosis.
Darley-Usmar and his colleagues say that the antioxidant MitoQ was able to prevent and neutralize free radicals before they damage the mitochondria, preventing a series of effects that ultimately leads to steatosis.
"There is not a promising pharmaceutical approaches to the prevention and reversal of long-term damage associated with the deposition of fat in the liver resulting from excessive alcohol consumption," said Darley-Usmar. "Our findings tell that MitoQ could be a useful tool for the treatment of liver damage by alcohol use that old habits."
"Previous studies have shown that MitoQ can be safely administered to humans for a long time," said Balu Chacko, Ph.D., co-researcher and initiator of the study. "Antioxidants could have the potential to improve the early stages of fatty liver disease in patients with alcoholic liver disease and non-alcoholics."
Annual records of Hepatology estimates that alcohol abuse cost $ 185 billion each year in the United States, and that 2 million people suffer from some form of alcoholic liver disease. As many as 90 percent of heart sirkosis connected with alcohol abuse and 30 percent of liver cancer.
Darley-Usmar, who is also a director of the Center for Free Radical Biology at UAB, said the team discussed with the National Institutes of Health to develop a whole family of drugs based on interaction with mitochondria. He said that such drugs may be effective in the treatment of cardiovascular disease, kidney disease and neurodegenerative disorders.
"We know that free radicals play a role in human disease, and we have developed antioxidants that can eliminate free radicals in the laboratory," he said. "Unfortunately, previous trials using antioxidants in humans have not been satisfactory. Difference with our findings is that we are targeting specific parts of the cell mitochondria. This is a unique approach, and this is one of the few pre-clinical trials that demonstrate effectiveness."
Darley-Usmar said the findings could also have a significant impact on the treatment of metabolic syndrome, a condition which grew so fast that affects approximately 50 million Americans, according to the American Heart Association.
"Metabolic syndrome is described as a complex interaction of factors that include obesity is caused by damage to the liver due to an increase in free radicals, hypoxia and deposition of fat," said Darley-Usmar. "It is quite similar to alcohol dependence hepatotoksisiti. Would be nice to see if an antioxidant such as MitoQ has therapeutic effect in preventing liver damage in those with metabolic syndrome."
The findings were published on April 21, 2011 in the journal Hepatology.
An antioxidant may prevent liver damage or liver caused by excessive alcohol consumption, according to research from the University of Alabama at Birmingham.
These findings could indicate how treatments to reverse steatosis, or fatty deposits in the liver that can lead to sirkosis and cancer. The research team led by Victor Darley-Usmar, Ph.D., professor of pathology at UAB, introduced an antioxidant called mitochondria-targeted ubiquinone, or MitoQ, to the mitochondria rats given alcohol every day for five to six weeks in an amount sufficient to Excessive alcohol consumption is equal to humans.
Chronic alcoholics, those who drink excessively every day, experiencing accumulation of fat in liver cells. When alcohol is metabolized in the liver, he creates free radicals that damage mitochondria in liver cells and prevent them to use a sufficient amount of oxygen to produce energy. Moreover, the low oxygen condition called hypoxia worsens mitochondrial damage and support the formation of fatty deposits that can lead to sirkosis.
Darley-Usmar and his colleagues say that the antioxidant MitoQ was able to prevent and neutralize free radicals before they damage the mitochondria, preventing a series of effects that ultimately leads to steatosis.
"There is not a promising pharmaceutical approaches to the prevention and reversal of long-term damage associated with the deposition of fat in the liver resulting from excessive alcohol consumption," said Darley-Usmar. "Our findings tell that MitoQ could be a useful tool for the treatment of liver damage by alcohol use that old habits."
"Previous studies have shown that MitoQ can be safely administered to humans for a long time," said Balu Chacko, Ph.D., co-researcher and initiator of the study. "Antioxidants could have the potential to improve the early stages of fatty liver disease in patients with alcoholic liver disease and non-alcoholics."
Annual records of Hepatology estimates that alcohol abuse cost $ 185 billion each year in the United States, and that 2 million people suffer from some form of alcoholic liver disease. As many as 90 percent of heart sirkosis connected with alcohol abuse and 30 percent of liver cancer.
Darley-Usmar, who is also a director of the Center for Free Radical Biology at UAB, said the team discussed with the National Institutes of Health to develop a whole family of drugs based on interaction with mitochondria. He said that such drugs may be effective in the treatment of cardiovascular disease, kidney disease and neurodegenerative disorders.
"We know that free radicals play a role in human disease, and we have developed antioxidants that can eliminate free radicals in the laboratory," he said. "Unfortunately, previous trials using antioxidants in humans have not been satisfactory. Difference with our findings is that we are targeting specific parts of the cell mitochondria. This is a unique approach, and this is one of the few pre-clinical trials that demonstrate effectiveness."
Darley-Usmar said the findings could also have a significant impact on the treatment of metabolic syndrome, a condition which grew so fast that affects approximately 50 million Americans, according to the American Heart Association.
"Metabolic syndrome is described as a complex interaction of factors that include obesity is caused by damage to the liver due to an increase in free radicals, hypoxia and deposition of fat," said Darley-Usmar. "It is quite similar to alcohol dependence hepatotoksisiti. Would be nice to see if an antioxidant such as MitoQ has therapeutic effect in preventing liver damage in those with metabolic syndrome."
The findings were published on April 21, 2011 in the journal Hepatology.
Advice For the Heart And Soul
Advice For the Heart And Soul
Soul sepertilah a field, which must be watered by rain droplets wisdom and advice, so it is not barren and desolate. How miserable souls arid, barren soul surely will not be able to feel the sense of happiness and feel the essence of life.
If we look at the barren desert, clad worldly dust that covered the true light of the soul, then we will understand, how the advice and quotes words to remind us what life is needed.
Here is some advice to heart and set your soul that might be meaningful to our life's journey. I realize that this advice is just such and only as much as a drop of water, but even so, it would seem worthwhile if a drop of dew is present before a traveler lost in a barren desert parched soul.
Life Advice
(Adapted from various words of the scholars, hadiths and Islamic books)
Be thankful if this happens to your heart: you feel happy when doing good deeds, and you feel kegelisahaan while doing bad deeds. It signifies that your heart is still alive and you are still loved by God.
Hopefully a drop of water advice and words of advice the soul and the heart is beneficial for you to wade the swift waves of life. Remember, everything starts from the heart, and will lead in the liver.
Soul sepertilah a field, which must be watered by rain droplets wisdom and advice, so it is not barren and desolate. How miserable souls arid, barren soul surely will not be able to feel the sense of happiness and feel the essence of life.
If we look at the barren desert, clad worldly dust that covered the true light of the soul, then we will understand, how the advice and quotes words to remind us what life is needed.
Here is some advice to heart and set your soul that might be meaningful to our life's journey. I realize that this advice is just such and only as much as a drop of water, but even so, it would seem worthwhile if a drop of dew is present before a traveler lost in a barren desert parched soul.
Life Advice
(Adapted from various words of the scholars, hadiths and Islamic books)
Life is actually located between two very scary, that his sins in the past, which he did not know what God's will be done with it later, and the rest of his life that he did not know what will happen.stupided us? When we are so concerned with physical food that enter into ourselves, and berpantangan refused entry into the stomach to the foods that can damage the body, but let in the foods that can damage the spiritual soul.
Indeed on the day when everything is created in pairs, then dipasangkanlah laziness with weakness, and from both born squalor.When we fear the pain of a hot fire, why do we allow the embers of anger and hatred hurt our souls?
Distance yourself from debt, because debt makes the heart restless at night, and low self-made in the daytime.Do not keep busy your heart with sorrow of the past, because with it you will lose the joy and happiness in the future.
Carelessness and haste is a mental illness, because they will soon feel remorse.Verily Allah sent down wealth, power and disasters as a test for people who want to think. But the wealth, power and disasters will be disaster for the people foolish and hard-hearted.
Ask the other person is sacrilege in life, ruining modesty, dehumanizing, and is given a human form of poverty in itself.The wise person is not able to stop the war the two countries, not the ones who are able to relieve the human heart that was a swarm of fire burning with anger, but a wise man is one who is able to put everything in proper place.
Be like a palm tree, that whatever any part of it is to always provide the benefits and advantages.There are six things that are not present in those who loved God: perseverance, complaints, stiffness, malice, falsehood and injustice.
When you see someone looking for the sins of others and fuss, but forgetting his own sin, know that the person was in the punishment of God.There has been no certainty in this world without the slightest doubt as it was Death. But so many people who hesitate and forget that it will soon happen to him, without notice, sooner or later.
Beautiful flowers only grow on the ground is soft, not on rock. Similarly, science and wisdom, hearts grow only those who humble themselves, not in the hearts of the proud and hard-hearted.The tongue is a measure to assess the arrogance and stupidity, and scales to determine a person's intelligence and wisdom.
Be thankful if this happens to your heart: you feel happy when doing good deeds, and you feel kegelisahaan while doing bad deeds. It signifies that your heart is still alive and you are still loved by God.
Hopefully a drop of water advice and words of advice the soul and the heart is beneficial for you to wade the swift waves of life. Remember, everything starts from the heart, and will lead in the liver.
Subscribe to:
Posts (Atom)
